Improved IVF Outcomes After Treatment of Subclinical Hypothyroidism in Infertile Women.

Improved IVF Outcomes After Treatment of Subclinical Hypothyroidism in Infertile Women.
Rahman AH, Abbassy HA, Elatif Abbassy AA. Obstetrics & Gynecology Department, Alexandria University.

To assess the consequences of treatment of maternal subclinical hypothyroidism SH on infertility outcome.Methods: We conducted a prospective, randomized trial for the assisted reproductive technology program at the Shatby University Hospital for Women in Alexandria, Egypt.A total of seventy infertile women with subclinical hypothyroidism were counseled and consented for the experimental design of the IVF-ICSI program between April 1, 2006 and April 22, 2007.These 70 patients were divided into two groups, an intervention group treated with L-thyroxin (LT4) (group A) and another group treated with placebo (group B). All patients received controlled ovarian stimulation protocol.Results: The mean value of TSH was significantly lower in the treated group A compared to the untreated group B (1.1+/-0.3 muIU/ml group A, versus 4.9+/-0.7 muIU/ml group B); the mean number of retrieved oocytes were equal in both groups (6.19+/-0.74 group A, versus 6.08+/-0.79 group B); the miscarriage rate was significantly lower in the treated group than the control group (9% group A, versus 13% group B); and the clinical pregnancy rate, as well as the delivery rate, were significantly improved in the treated group versus the placebo group (35% group A, versus 10% group B) and (26% group A, versus 3% group B), respectively, indicating that the quality and not the quantity of retrieved oocytes was more important.Conclusion: This preliminary data suggest that L-Thyroxin supplementation is recommended to achieve clinical pregnancies in subclinical hypothyroid women undergoing an IVF-ICSI program.


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